An explosion has killed 10 people at a Pakistani hospital where victims of an earlier bombing were being treated, police and doctors say.
At least 12 people were killed in the first attack on a bus of Shia Muslims heading to a religious festival. About 50 people were injured in the attack, and were taken to Jinnah hospital in Karachi.
About an hour later there was a large blast just outside the emergency ward of the hospital, police said.
Shia Muslims are marking the end of the Arbaeen religious festival, with Friday being the final and most important day of 40 days of mourning for the Prophet Muhammad's grandson.
Also on Friday, at least 27 Shia Muslims were killed in the Iraqi city of Karbala as they took part in a major Arbaeen event.
Approximately a million Shia Muslim pilgrims are in Karbala to visit the Imam Hussein shrine at the end of commemorations.
In Karachi, the first attack took place on the main road of the country's commercial centre.
It was not clear whether the motorcycle bomb was rammed into the bus by a suicide bomber or was parked by the side of the road.
Karachi police chief Waseem Ahmad said it was too soon to say what exactly had happened.
"We are examining the site. We are collecting the evidence. We are taking witness statements and then we will say something concrete," he said.
Security cordon
The bus was one of dozens used to transport Shia mourners from all over the city to a central procession.
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The main mourning procession is being held on MA Jinnah Road, which is guarded on all sides by heavy security to prevent a repeat of an attack on a Shia march in December which killed 43 people.
But the attacker on Friday chose a different target, away from the security cordon.
At the hospital a local journalist said he saw six bodies from the second blast, and doctors had confirmed a total of 10 people were killed.
Mr Ahmad said the procession was continuing despite the attack.
Sectarian tension between the Shia minority and the Sunni majority rose after the December attack, and riots erupted.
Tension remains high, and paramilitary troops were deployed in the city days ago amid deadly clashes between rival political groups.
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